サントリーグローバルイノベーションセンター

Randomized, double-blind, crossover, placebo-controlled clinical trial to evaluate the effects of chicken hot water extract on insulin secretion.
European Review for Medical and Pharmacological Sciences、26(7), 2422-2430

Characteristics of the glycometabolic categories based on the oral glucose tolerance test results in Japanese adults without diabetes
Eur Rev Med Pharmacol Sci.26(8), 2765-2774

Plasma NfL is associated with mild cognitive decline in patients with diabetes.
Psychogeriatrics.22(3), 353-359

Food-derived antioxidant ergothioneine improves sleep difficulties in humans
Journal of Functional Foods, 95(2022), 105165

Identifying Glucose Metabolism Status in Nondiabetic Japanese Adults Using Machine Learning Model with Simple Questionnaire.
Comput Math Methods Med. 2022, 1026121

Effect of quercetin glycosides on cognitive functions and cerebral blood flow: a randomized, double-blind, and placebo-controlled study
European Review for Medical and Pharmacological Sciences, 26(23), 8700-8712

Automated Bowel Sound and Motility Analysis with CNN Using a Smartphone
Sensors、23(1),  407

Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study
J Epidemiol. JE20220232

Discovery of natural TRPA1 activators through pharmacophore-based virtual screening and a biological assay
Bioorganic & Medicinal Chemistry Letters Volume 31, 1 January 2021, 127639

Estimation of water intake from food moisture in the Japanese diet using a cooking‐based conversion factor for water content
Journal of Food Science Volume 86(2),12 January 2021, 266-275

Anthocyanin 5,3′-aromatic acyltransferase from Gentiana triflora, a structural insight into biosynthesis of a blue anthocyanin
Phytochemistry 186, 112727, 2021

ゴマリグナンの酵素進化から学ぶ特化代謝観
ファルマシア誌 Vol57, No8 (2021), 715-720

Validity of a selective recall method for assessing habitual water intake and hydration status
Eur Rev Med Pharmacol Sci. 2021;25(21):6623-6632.

Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis
Int. J. Environ. Res. Public Health 2021, 18(17), 8947

Evaluation of 3-Methylbutanoic Acid Methyl Ester as a Factor Influencing Flavor Cleanness in Arabica Specialty Coffee
Applied Sciences, June 2021, 11(12), 5413

Development of violet transgenic carnations and analysis of inserted transgenes
The Carnation Genome pp 135-146 2020 Springer

Hydrophobic interactions at subsite S1′ of human dipeptidyl peptidase IV contribute significantly to the inhibitory effect of tripeptides
Heliyon Volume 6, Issue 6, June 2020, e04227

Identification of compounds in red wine that effectively upregulate aquaporin-3 as a potential mechanism of enhancement of skin moisturizing
Biochemistry and Biophysics Reports Volume 24, December 2020, 100864

(+)-Sesamin-oxidizing CYP92B14 shapes specialised lignan metabolism in sesame
The Plant Journal 2020 Nov;104(4):1117-1128.

Subacute Ingestion of Caffeine and Oolong Tea Increases Fat Oxidation without Affecting Energy Expenditure and Sleep Architecture: A Randomized, Placebo-Controlled, Double-Blinded Cross-Over Trial
Nutrients 2020 Nov 28;12(12):3671.

Compromised chitin synthesis in lager yeast affects its Congo red resistance and release of mannoproteins from the cells
FEMS Microbiology Letters, Volume 367, Issue 22, November 2020, fnaa181

An Increase in Specific Discharge With Catchment Area Implies That Bedrock Infiltration Feeds Large Rather Than Small Mountain Headwater Streams
Water Resources Research, 56(9), September 2020, e2019WR025658.

Key Odorants in Japanese Roasted Barley Tea (Mugi-Cha) - Differences between Roasted Barley Tea Prepared from Naked Barley and Roasted Barley Tea Prepared from Hulled Barley
J. Agric. Food Chem. 2020, 68, 9, 2728–2737

Glycoside‐specific glycosyltransferases catalyze regio‐selective sequential glucosylations for a sesame lignan, sesaminol triglucoside
The Plant Journal, 101(5), 2020: 1221-1233

Effects of oligomeric proanthocyanidins (OPCs) of red wine to improve skin whitening and moisturizing in healthy women – a placebo-controlled randomized double-blind parallel group comparative study
European Review for Medical and Pharmacological Sciences, 2020; 24: 1571-1584

Identification of a new class of non-electrophilic TRPA1 agonists by a structure-based virtual screening approach
Bioorganic & Medicinal Chemistry Letters, 30 (2020) 127142

Effect of Increased Daily Water Intake and Hydration on Health in Japanese Adults
Nutrients, 2020, 12(4), 1191

Evaluation and Interpretation of 9 Body Constitution Scores of CCMQ-J by Seven Independent Questionnaires
Japanese Journal of Complementary and Alternative Medicine, September 2020; 16(2): 79-93

RNA-seq analysis of diet-driven obesity and anti-obesity effects of quercetin glucoside or epigallocatechin gallate in Drosophila adults
European Review for Medical and Pharmacological Sciences, 2019; 23: 857-876

Green Tea Intake and Risks for Dementia, Alzheimer’s Disease, Mild Cognitive Impairment, and Cognitive Impairment: A Systematic Review
Nutrients 2019, 11(5), 1165

Intake of arachidonic acid-containing lipids in adult humans: dietary surveys and clinical trials
Lipids in Health and Disease, volume 18, Article number: 101 (2019)

青い花実現に道を開く　ネモフィラのフラボン糖転移酵素の同定
バイオサイエンスとインダストリー. Vol.77 No.3, 2019年5月, p.250-251

中医体質と生活習慣病リスクファクターの関連性に関する横断的研究
日本補完代替医療学会誌　2019年16巻2号 p.95-104

炭酸水の刺激は体温低下に影響するか
食と医療2019 10号

Identification of the genes that regulate ornamental characters using the Rosa multiflora genome database (http://rosa.kazusa.or.jp/)
Acta Horticulturae Book No.1232 (2019) Proceedings of the VII International Symposium on Rose Research and Cultivation, 111-118

Specific Kieselguhr Increased Hop Yield Over Several Years
Journal of Agricultural Science, Vol. 10, No. 11; 2018: p91

How Inter-Basin Transfer of Water Alters Basin Water Stress Used for Water Footprint Characterization
Environments 2018, 5(9), 105

Multi-Sip Time–Intensity Evaluation of Retronasal Aroma after Swallowing Oolong Tea Beverage
Foods 2018, 7, 177

Identification and Characterization of Novel Nemophila menziesii Flavone Glucosyltransferases that Catalyze Biosynthesis of Flavone 7,4'-O-Diglucoside, a Key Component of Blue Metalloanthocyanins.
Plant and Cell Physiology (2018) 59(10), 2075-2085

Molecular cloning of flavonoid biosynthetic genes and biochemical characterization of anthocyanin O-methyltransferase of Nemophila menziesii Hook. and Arn
Plant Biotechnology, 35, 9–16 (2018)

MAL73, a novel regulator of maltose fermentation, is functionally impaired by single nucleotide polymorphism in sake brewing yeast
PLoS ONE (2018), 13(6): e0198744.　

Physical interactions among flavonoid enzymes in snapdragon and torenia reveal the diversity in the flavonoid metabolon organization of different plant species
The Plant Journal, 2018, 94(2) 372-392

Transgenic Research in Floricultural Crops
Genetic Engineering of Horticultural Crops. Academic Press, Elsevier, Chapter 6, pp. 121–136 (2018).

Influence of Apple Mosaic Virus on the Growth, Yield, and Qualities of Saaz Hop
Journal of Plant Sciences, 2017 5(5) 152-159

Economic aspects of virtual water trade
Environ. Res. Lett. 12(4), 2017

Oral carbonation modulates subjective appetite and gastric myoelectrical activity in young women
Journal of Nutritional Science and Vitaminology, 63,186-192,2017

Analysis of Active Components on Oral Fat Sensations in Oolong Tea
Food Science and Technology Research, 23(1), 71-78, 2017

Genome sequence and analysis of the Japanese morning glory Ipomoea nil
Nature Communications 7, Article number: 13295 (2016)

De Novo Transcriptomes of Forsythia koreana Using a Novel Assembly Method: Insight into Tissue- and Species-Specific Expression of Lignan Biosynthesis-Related Gene
PLoS ONE 11(10): e0164805 (2016)

臭質の同定と違和感評定に基づいた消費者による食品香料の選定方法
アロマリサーチ、17(3) 284-289, 2016

Volatile Glycosylation：A story of glycosyltransferase for volatiles.
Plant Specialized Metabolism: Genomics, Biochemistry, and Biological Functions. CRC Press, Chapter 11, p257-281.

Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and -independent mechanisms.
Endocr J. (2016), 63(8): 715-725

青いバラ　ー　遺伝子組換えがかなえた不可能の花
BIOSTORY（ビオストーリー） (2016) 25,56-63

植物が香りを繋ぎとめるマシナリー
アロマリサーチ、17(2) 182-184, 2016

茶の香気成分の貯蔵メカニズム茶は香りをどのように繋ぎとめるのか？
日本家政学会誌 Vol. 67(No.4), p30-34

Potential Impacts of Food Production on Freshwater Availability Considering Water Sources
Water 2016, 8(4), 163

茶の香りの貯蔵に関わる配糖体化酵素の解明
バイオサイエンスとインダストリー、2016年 VOL.74 NO.2、129-131

The influence of pruning and harvest timing on hop aroma, cone appearance, and yield
Food Chemistry, Volume 202, 1 July 2016, Pages 15-22

Next-generation sequencing analysis of lager brewing yeast strains reveals the evolutionary history of interspecies hybridization
DNA Research 2016 Feb; 23(1): 67–80

Disruption of lig4 improves gene targeting efficiency in the oleaginous fungus Mortierella alpina 1S-4
Journal of Biotechnology, Volume 208, 20 August 2015, Pages 63-69

Gene targeting in the oil-producing fungus Mortierella alpina 1S-4 and construction of a strain producing a valuable polyunsaturated fatty acid
Current Genetics, 61, pages579–589 (2015)

Identification of 3-Methylbutanoyl Glycosides in Green Coffea Arabica Beans as Causative Determinants for the Quality of Coffee Flavors.
Journal of Agricultural Food Chemistry 2015, 63(14), 3742-3751

Volatile Glycosylation in Tea Plants: Sequential Glycosylations for the Biosynthesis of Aroma β-Primeverosides Are Catalyzed by Two Camellia sinensis Glycosyltransferases
Plant Physiology, Volume 168, Issue 2, June 2015, Pages 464–477

Essences in Mtabolic Engineering of Lignan Biosynthesis
Metabolites, 5(2), 270-290 (2015)

二次代謝産物代謝工学の産業利用に関する将来展望（木材学会60周年記念号への依頼原稿）
木材学会誌61号

肥満者に対するケルセチン配糖体（酵素処理イソクエルシトリン）配合茶飲料の体脂肪低減作用および安全性の検証
薬理と治療 (2015) 43/2,181-194

The draft genome of hop, an essence of brewing
Plant and Cell Physilogy (2015) 56/3,428-441

生物工学会誌　バイオよもやま話（続・生物工学基礎講座）流加培養による酵母の生産
生物工学会 (2015) 93,32-34

Metabolic Engineering of Flower Color Pathways Using Cytochromes P450
Fifty Years of Cytochrome P450 Research (2014) ,207-232 (Ed. Yamazaki, Springer)

Genetic control and evolution ofanthocyanin methylation
Plant Physiology (2014) 165/3,962-977

遺伝子組換えカーネーション「ムーンダスト」を用いた導入遺伝子の検出と導入遺伝子に由来するアントシアニジンの検出のためのプロトコール
日本植物細胞分子生物学会

Uridine diphoephate glucose:lignan glucpsyltransferase activity of UGT71C1 toward pinoresinol and lariciresinol
Plant Biotechnology (2014) 31, 561-566

A new O-methyltransferase for monolignol synthesis in Carthamum tinctorius
Plant Biotechnology (2014) 31, 545-553

Expansion of specialized metabolism-related superfamily genes via whole genome dupulicaioduring in angiosperm evolution.
Plant Biotechnology (2014) 31, 579–584

Identification and characterization of Camellia sinensis glucosyltransferase, UGT73A17: A possible role in flavonol glucosylation
Plant Biotechnology (2014) 31, 573–578

Mode-of-action and evoluton of methylenedioxybridge forming P450s
Plant Biotechnology (2014) 31, 493–503

炭酸水による口腔への刺激が深部・末梢体温に及ぼす作用
日本栄養食糧学会誌 (2014) 67,19-25

Sequence analysis of the genomic of carnation (Dianthus caryophyllus L.)
DNA Research (2014) 2/3 ,231-241

Evolution and diversity of the 2-oxoglutarate-dependent dioxygenase (2OGD) superfamily in plants
The Plant Journal (2014) 78/2 ,328–343

A chalcone isomerase-like protein enhnaces flavonoid production
The Plant Journal (2014) 78/2 ,294–304

characterization of a trifunctional fatty acid desaturase from oleaginous filamentous fungus Mortierella alpina 1S-4 using a yeast expression system
Journal of Bioscience and Bioengineering (2013) 116/6 ,672–676

青いバラの創生
アントシアニン研究会

Enhancement of phosphate absorption by garden plants by genetic engineering – A new tool for phytoremediation
BioMed Research International (2013), Article ID 182032, 7 pages

Genetic engineering of novel bluer colored chrysanthemums produced by dephinidin-based anthoctanin accumulation
Plant and Cell Physiology (2013) 54/10 ,1684-1695

Violet Chrysanthemums – Metabolic Engineering of Anthocyanin Biosynthetic PathwayResulted in Novel Petal Colours
Plant and Cell Physiology (2013) 54/10 ,1696-1710

A novel O-methyltransferase involved in the first methylation step of yatein biosynthesis in Anthriscussylvestris
Plant Biotechnology (2013) 30 ,375–384

Expression of flavonoid 3',5'-hydroxylase and acetolactate synthase genes in transgenic carnation: Safety
Journal of Agricultural and Food Chemistry (2013) 61/48 ,11711–11720

ウイスキー香気成分のストレス緩和作用
アロマリサーチ (2013) No.55, 273-275

High-throughput metabolic profiling of diverse green Coffea arabica beans identified tryptophan as a universal discrimination factor of immature beans
PLoS ONE (2013) 8/8 ,70098

自然にはない色の花を咲かせる〜青いバラを求めて
化学と教育 (2013) 61/9 ,452-453

Flower colour and cytochromes P450
Philosophical Transactions B (2013) 368: 20120432

ケルセチン配糖体（酵素処理イソクエルシトリン）配合飲料の継続摂取による肥満者の体肪低減効果
薬理と治療 (2012) 40/10 ,901-914

肥満者に対するケルセチン配糖体（酵素処理イソクエルシトリン）配合緑茶飲料の体脂肪低減作用および安全性の検証
薬理と治療 (2012) 40/6 ,495-503

The Effects of Carbonated Water upon Gastric and Cardiac Activities and Fullness in Healthy Young Women
Journal of Nutritional Science and Vitaminology (2012) 58/5 ,333-338

Opponency of astringent and fat sensations
Current Biology (2012) 22/19,R829-R830

Genetic Analysis of Chemosensory Traits in Human Twins
Chemical Senses (2012) 37/9 ,869-881

GENETIC ENGINEERING OF FLORICULTURAL CROPS: MODIFICATION OF FLOWER COLOUR, FLOWERING AND SHAPE
Acta Horticulturae (2012) 953 ,209-216

The Sg-1 Glycosyltransferase Locus Regulates Structural Diversity of Triterpenoid Saponins of Soybean
The Plant Cell (2012) 24/5 ,2123-2138

Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds
PLoS ONE 7(4): 35380

植物フラボノイドグリコシルトランスフェラーゼ：分子系統学と特異性発現機構
酵素工学ニュース (2012) 67,6-10

平行進化する基質特異性
化学と生物 (2012) 50/1,16-22

Functional analysis of Antirrhinum kelloggii flavonoid 3′-hydroxylase and flavonoid 3′,5′-hydroxylase genes; critical role in flower color and evolution in the genus Antirrhinum
Journal of Plant Research (2012) 125/3 ,451-456

特定保健用食品「黒烏龍茶 OTPP」の継続摂取による体脂肪低減効果の検証とその安全性
薬理と治療 (2011) 39/10 ,889-900

難消化性デキストリン配合炭酸飲料摂取による食後中性脂肪上昇抑制効果－プラセボ対照二重盲検ランダム化クロスオーバー試験－
薬理と治療 (2011) 39/9 ,813-821

CYP716A subfamily members are multifunctional enzymes in triterpenoid biosynthesis
Plant and Cell Physiology (2011) 52/12 ,2050-2061

Identification of Sc-type ILV6 as a target to reduce diacetyl formation in lager brewers' yeast.
Metabolic Engineering (2011) 13/6,638-647

青いバラとカーネーションの開発
青いバラとカーネーションの開発（2011）（鈴木正彦編）　植物の分子育種学、講談社

Simultaneous quantification of lignans in Arabidopsis thaliana by highly sensitive capillary liquid chromatography-electrospray ionization-ion trap mass spectrometry.
Plant Biotechnology (2011) 28/3 , 287-293

Effects of light on production of endogenous and exogenous lignans by Forsythia koreana wildtype and transgenic cells
Plant Biotechnology (2011) 28/3 ,331-337

The construction of transgenic Forsythia plants: comparative study of three Forsythia species.
Plant Biotechnology (2011) 28/3 ,273-280

ゴマリグナン生合成経路と代謝工学
バイオインダストリー (2011) 28/12, 5-11

Environmental risk assessment and field performance of rose (Rosa x hybrida) genetically modified for delphinidin production
Plant Biotechnology (2011) 28/2 ,251

Molecular based evidence for a lack of gene-flow between Rosa × hybrida and wild Rosa species in Japan
Plant Biotechnology (2011) 28/2 ,245

Biochemical and molecular characterization of anthocyanidin/flavonol 3-glucosylation pathways in Rosa × hybrida
Plant Biotechnology (2011) 28/2 ,239

Isolation of cDNAs encoding tetrahydroxychalcone 2'-glucosyltransferase activity from carnation, cyclamen, and catharanthus
Plant Biotechnology (2011) 28/2 ,231

Morphological changes of Rosa x hybrida by a chimeric repressor of Arabidopsis TCP3
Plant Biotechnology (2011) 28/2 ,149

The new FioreDB database provides comprehensive information on plant transcription factors and phenotypes induced by CRES-T in ornamental and model plants
Plant Biotechnology (2011) 28/2 ,123

Effect of photoperiod on growth of the plants, and sesamin content and CYP81A1 gene expression in the leaves of sesame (Sesamum indicum L.).
Environmental and Experimental Botany (2011) 75, 212-219

Engineering of the rose flavonoid biosynthetic pathway successfully generated blue-hued flowers accumulating delphinidin.
日本植物生理学会誌 (2007) 48/11 ,1589-1600